Postion : IAM-RE Director and Professor of Chemical Engineering
Phone: (502) 852 5170
Email:mttsen01@louisville.edu

Dr. Tseng has a longtime interest on the tumor vascular response to photodynamic therapy.  In collaboration with Dr. Victor Fingar they are examining the impact of multiple photosensitizer on the blood flow and tumor cell survival in a skin flap model. In the recent years, Dr. Tseng has also developed a strong interest in the neuronal responses to cerebral ischemia.  The primary model for the laboratory has been a cardiac arrest induced transient global ischemia in rat.  Besides using the model for putative neuroprotectant screening, his laboratory is interested in the issues related to the neuroimmunology and age related cerebral vulnerability.

Representative Publications:

• Tseng MT, Reed MWR, Ackerman D, Scheischke DA, Wieman TJ, Miller FN (1988) Photodynamic therapy induced ultrastructural alteration in microvasculature of the rat cremaster muscle. Photochem. and Photobiol. 48: 675-682.
• Tseng MT, Chan SA, Reid KH, Iyer VG (1997) C-fos immunoreactivity in transient global ischemic rats. Neurol Res 19: 89-91.
• Tseng MT, Chang CC (1999) Ultrastructural localization of hippocampal TNF - immunoreactive cells in rats following transient global ischemia. Brain Research 833:121-124.
• Althaus JS, Schmidt KR, Fountain ST, Tseng MT, Carroll RT, Galatsis P, Hall ED (2000) LC-MS/MS detection of peroxynitrite-derived 3-Nitrotyrosine in rat microvessels, Free Radic. Biol. Med. 29: 1085-1095.
• Schurr A, Payne RS, Tseng M (2001) et at Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia, Brain Research. 895 (1-2): 268-72.